Vyacheslav Palchevskiy, PhD

Biography

Publications

Weigt SS, Chang LC, Lari S, Palchevskiy V, Xue YY, Shino MY, Saggar R, Sayah D, Derhovanessian A, Lynch JP III, Ardehali A, Belperio JA. (2023). Immune Responses in the Lung Preceding a Diagnosis of Chronic Lung Allograft Dysfunction. Ann Transplant Res. 3(1):1017.

Didriksen, H., Molberg, Ø., Mehta, A., Jordan, S., Palchevskiy, V., Fretheim, H., Gude, E., Ueland, T., Brunborg, C., Garen, T., Midtvedt, Ø., Andreassen, A. K., Lund-Johansen, F., Distler, O., Belperio, J., & Hoffmann-Vold, A. M. (2022). Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension.ÌýFrontiers in immunology,Ìý13, 991743. .

Tennøe, A. H., Murbræch, K., Didriksen, H., Ueland, T., Palchevskiy, V., Weigt, S. S., Fretheim, H., Midtvedt, Ø., Garen, T., Brunborg, C., Aukrust, P., Molberg, Ø., Belperio, J. A., & Hoffmann-Vold, A. M. (2022). Serum markers of cardiac complications in a systemic sclerosis cohort.ÌýScientific reports,Ìý12(1), 4661. .

Didriksen, H., Molberg, Ø., Fretheim, H., Gude, E., Jordan, S., Brunborg, C., Palchevskiy, V., Garen, T., Midtvedt, Ø., Andreassen, A. K., Distler, O., Belperio, J., & Hoffmann-Vold, A. M. (2021). Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis.ÌýArthritis & rheumatology (Hoboken, N.J.),Ìý73(7), 1277–1287. .

Hoffmann-Vold A.M., Weigt S.S., Saggar R.,ÌýPalchevskiy, V., Volkmann, E.R., Liang, L.L., Ross, D., Ardehali, A., Lynch, J.P., Belperio, J.A.. (2019). Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease.ÌýEBioMedicine. 50:379-386. PMID:31732480

Weigt, S.S.,ÌýWang, X.,ÌýPalchevskiy, V.,ÌýLi, X.,ÌýPatel, N.,ÌýRoss, D.J.,ÌýReynolds, J.,ÌýShah, P.D.,ÌýDanziger-Isakov, L.A.,ÌýSweet, S.C.,ÌýSinger, L.G.,ÌýBudev, M.,ÌýPalmer, S., Belperio, J.A. (2019). Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection.Ìý°Õ³ó±ðÌýÌý38(8):845-855. PMID: 31122726.

Palchevskiy, V, Xue, Y.Y., Kern, R., Weigt, S.S., Gregson, A.L., Song, S.X., Fishbein, M.C., Hogaboam, C.M., Sayah, D.M., Lynch, J.P., Keane, M.P., Brooks, D.G., Belperio, J.A. (2019). CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection.ÌýJCI Insight. 4(12):e121782

Hoffmann-Vold, A.M., Weigt, S.S.,ÌýPalchevskiy, V., Volkmann, E., Saggar, R., Li, N., Midtvedt, Ø., Lund, M.B., Garen, T., Fishbein, M.C., Ardehali, A., Ross, D.J., Ueland, T., Aukrust, P., Lynch, J.P., Elashoff, R.M., Molberg, Ø., Belperio, J.A. (2018). Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis.ÌýPLoS One. 13(11):e0206545. doi: 10.1371/journal.pone.0206545. PMCID: PMC6245508

Weigt, S.S., Wang, X.,ÌýPalchevskiy, V., Patel, N., Derhovanessian, A., Shino, M.Y., Sayah, D.M., Lynch, J.P., Saggar, R., Ross, D.J., Kubak, B.M., Ardehali A, Palmer S, Husain S, Belperio JA. (2018).ÌýGene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung AllograftÌýTransplantation. 102(6):986-993. PMID: 29256975

Hoffmann-Vold AM, Hesselstrand R, Fretheim H, Ueland T, Andreassen AK, Brunborg C,ÌýPalchevskiy V, Midtvedt Ø, Garen T, Aukrust P, Belperio JA, Molberg Ø. (2018). CCL21 as a potential serum biomarker for pulmonary arterial hypertension in Systemic Sclerosis.ÌýArthritis Rheumatol.Ìýdoi: 10.1002/art.40534. [Epub ahead of print].

Weigt SS, Wang X,ÌýPalchevskiy V, Patel N, Derhovanessian A, Shino MY, Sayah DM, Lynch JP 3rd, Saggar R, Ross DJ, Kubak BM, Ardehali A, Palmer S, Husain S, Belperio JA. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung Allograft.ÌýTransplantation.Ìýdoi: 10.1097/TP.0000000000002058. [Epub ahead of print].

Shino MY, Weigt SS, Li N,ÌýPalchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Huynh RH, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. (2017). The prognostic importance of CXCR3 chemokine during organizing pneumonia on the risk of chronic lung allograft dysfunction after lung transplantation.ÌýPLoS One. 12(7):e0180281. doi: 10.1371/journal.pone.0180281. eCollection 2017

Weigt SS,ÌýPalchevskiy V,ÌýBelperio JA. (2017). Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction.ÌýJ Clin Invest. 127(6), 2022-2029. doi: 10.1172/JCI93537.

Weigt SS, Wang X,ÌýPalchevskiy V, Gregson AL, Patel N, DerHovanessian A, Shino MY, Sayah DM, Birjandi S, Lynch JP 3rd, Saggar R, Ardehali A, Ross DJ, Palmer SM, Elashoff D, Belperio JA. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction.ÌýPLoS One. 12(1):e0169894. doi: 10.1371/journal.pone.0169894.

Birjandi SZ,ÌýPalchevskiy V, Xue YY, Nunez S, Kern R, Weigt SS, Lynch JP 3rd, Chatila TA, Belperio JA. (2016). CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis.ÌýAm J Pathol, 186(8), 2008-20. doi: 10.1016/j.ajpath.2016.03.020.

DerHovanessian A, Weigt SS,ÌýPalchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP 3rd, Elashoff RM, Belperio JA. (2015). The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.ÌýAm J Transplant, 16(2), 640-9. doi: 10.1111/ajt.13475

Gregson AL, Hoji A, Injean P, Poynter ST, Briones C,ÌýPalchevskiy V,ÌýWeigt SS, Shino M, Derhovanessian A, Sayah D, Saggar R, Ross D, Ardehali A, Lynch Iii JP, Belperio JA. (2015). Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection.ÌýAm J Respir Crit Care Med, 192(12), 1490-503. doi: 10.1164/rccm.201503-0558OC

Shino MY, Weigt SS, Li N,ÌýPalchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. (2013).Ìý CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction.ÌýAm J Respir Crit Care Med, 188(9), 1117-25. doi: 10.1164/rccm.201305-0861OC

Gregson AL, Wang X, Weigt SS,ÌýPalchevskiy V, Lynch JP 3rd, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA. (2013). Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation.ÌýAm J Respir Crit Care Med, 187(5), 518-26. doi: 10.1164/rccm.201207-1228OC

Weigt SS, Derhovanessian A, Liao E, Hu S, Gregson AL, Kubak BM, Saggar R, Saggar R,ÌýPalchevskiy V, Fishbein MC, Lynch JP 3rd, Ardehali A, Ross DJ, Wang HJ, Elashoff RM, Belperio JA. (2012). CXCR3 chemokine ligands during respiratory viral infections predict lung allograft dysfunction.ÌýAm J Transplant, 12(2), 477-84.

Abstracts

Hoffmann-Vold A, Palchevskiy V, Diep P, Didriksen H, Talaro Ramsli M, Zhou J, Lari S, Pachera E, Durheim M, Molberg Ø, Distler O, Weigt S, Belperio J. High-throughput Screening Identifies Specific Molecular Markers for ILD in Patients with Rheumatic Diseases [abstract].ÌýArthritis Rheumatol.Ìý2024; 76 (suppl 9).

Didriksen H, Molberg Ø, Mehta A, Jordan S, Fretheim H, Gude E, Ueland T, Brunborg C, Palchevskiy V, Garen T, Midtvedt Ã, Andreassen A, Lund-Johansen F, Distler O, Belperio J, Hoffmann-Vold A. The Role of CCL21 in Serum Samples from Systemic Sclerosis Patients [abstract].ÌýArthritis Rheumatol.Ìý2022; 74 (suppl 9).

Barua, I., Palchevskiy, V., Fretheim, H., Didriksen, H., Garen, T., Aaløkken, T. M., Weigt, S. S., Molberg, Ø., Belperio, J. and Hoffmann-Vold, A. M. (2022). High levels of both CCL2 and CCL17 were associated with more severe SSc-ILD. Annals of the Rheumatic Diseases. 81:762.

LeMaster, W., Stapper, A. P., Barjaktarevic, I., Zhou, H., Palchevskiy, V., Buhr, R., Ingersoll, S., Tashkin, D. P., Weigt, S., Cooper, C. B., Li, C., Phee, H., & Belperio, J. A. (2020). Nasal swab RNA-seq differentiates COPD from non-COPD healthy patients: A pilot single center study. Am J Respir Crit Care Med. 201:A4002.

S. Weigt, X. Wang,ÌýV. Palchevskiy, N. D. Patel, D. J. Ross, Y. M. Shino, J. M. Reynolds, P. Shah, L. G. Singer, M. M. Budev, S. M. Palmer, J. A. Belperio. (2018). Gene Expression Profiling of BAL Cells and PBMC During Lung Allograft Acute Cellular Rejection.ÌýAmerican Journal of Respiratory and Critical Care Medicine. 197:A4740

A.-M. Hoffmann-Vold, H. Didriksen, H. Fretheim, E. Gude,ÌýV. Palchevskiy, T. Garen, Ø. Midtvedt, A. Andreassen, J. Belperio ,Ø.Molberg. (2018). FRI0431 Dysregulation of lymphangiogenetic factors in systemic sclerosis patients with pulmonary arterial hypertension.ÌýAnnals of the Rheumatic Diseases. 77:745-746.

Huynh, R. Saggar, N. Li,ÌýV. Palchevskiy, N. Patel, Y. Xue, R. Kern, R. Saggar, J. P. Lynch 3rd, D. J. Ross, R. Elashoff,R. H. Huynh S. Weigt, J. A. Belperio (2017). Elevated Baseline Concentrations Of Cxcl-9 And -10 Are Associated With Irreversible Vascular Remodeling Of The Pulmonary Circulation In Portopulmonary Hypertension.ÌýAmerican Journal of Respiratory and Critical Care Medicine. 195:A4230

S.S. Weigt, X. Wang,ÌýV. Palchevskiy, N. Patel, A. DerHovanessian, M.Y. Shino, D. Sayah, A.L. Gregson, J.P. Lynch III, R. Saggar, D.J. Ross, A. Ardehali, D. Elashoff, J.A. Belperio. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction.ÌýAnn Am Thorac Soc.Ìý3, S252. doi: 10.1513/AnnalsATS.201608-618MG

A. DerHovanessian,ÌýV. Palchevskiy, S. Weigt, M. Shino, A. Gregson, D. Sayah, J. P. Lynch, R. Saggar, D. Ross, A. Ardehali, R. M. Elashoff, J. A. Belperio. (2016). The Role Of Hyaluronan-CD44 Biology During Primary Graft Dysfunction In Lung Transplant Recipients.ÌýAm J Respir Crit Care Med.Ìý193, A3452.

S.S. Weigt, X. Wang,ÌýV. Palchevskiy, N. Patel, A. DerHovanessian, M.Y. Shino, D. Sayah, A.L. Gregson, J.P. Lynch III, R. Saggar, D.J. Ross, A. Ardehali, D. Elashoff, J.A. Belperio. (2016) Gene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung Allograft.ÌýJournal of Heart and Lung transplantation. 35(4), S312.

A.-M. Hoffmann-Vold, R. Huynh, E. Volkmann,ÌýV. Palchevskiy, Ø. Midtvedt, T. Garen, A. Der Hovanessian, S. Weigt, M. Fishbein, A. Ardehali, D. Ross, R. Saggar, J. Lynch, P. Aukrust, T. Ueland, R. Elashoff, Ø. Molberg, J. Belperio. (2016). Augmented Concentrations of Cx3cl1 Are Associated with Progressive Interstitial Lung Disease in Systemic Sclerosis.ÌýAnn Rheum Dis.Ìý2016;75:527 doi:10.1136/annrheumdis-2016-eular.4406

R. Huynh, R. Saggar, N. Li, R. Elashoff, E. Volkmann, R. Saggar, A. Derhovanessian, D. Ross, M. Fishbein, J. Lynch, V. Palchevskiy, S. Weigt, J. Belperio. (2015). Increased Concentrations of CCL5, PDF-AA and PDGF-BB are Associated with Irreversible Vascular Remodeling of the Pulmonary Circulation in Interstitial Lung Disease Associated Pulmonary Arterial Hypertension.ÌýAnn Rheum Dis.74, 654-655. doi:10.1136/annrheumdis-2015-eular.2098

R. Huynh, M. Y. Shino, A. Derhovanessian, D. M. Sayah, R. Saggar,ÌýV. Palchevskiy,ÌýA. Ardehali, D. J. Ross, J. P. Lynch, S. Weigt, J. A. Belperio. (2015). Th2 Products IL-4 And IL-13 Are Associated With Rapidly Progressive Idiopathic Pulmonary Fibrosis.ÌýAm J Respir Crit Care MedÌý191, A2166

A Der Hovanessian,ÌýV Palchevskiy, SS Weigt, MY Shino, AL Gregson, BM Kubak, JP Lynch, R Saggar, DJ Ross, A Ardehali, R. Elashoff and JA Belperio. (2013). The CCL2/CCR2 Axis in Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome Following Lung Transplantation.ÌýThe Journal of Heart and Lung Transplantation. 32(4), S28–S29.